Tylenol's Impact on Glutathione and Liver Damage Tylenol And Alcohol: Dangers, Safe Alternatives & Treatment Glutathione You Are The Healer The parent compounds of acetaminophen (US market in 1955 in the US as Tylenol and other products) were first discovered in 1886 (acetanilide) and 1887 (phenacetin). These were the earliest synthetic fever Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.