I'm Dr Ashley Mayer . I'm a practicing integrative physician, and also a mama to two great kiddos of my own! If you caught my post on Ibuprofen a few days ago, Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol & Liver Health: Glutathione Boost