How Many Puffs of Vape are Equal to a Cigarette? EDGE Vaping The (Financial) Case Against JUUL by Brandon Brissart Medium Vape vs Cigarette Nicotine: How Many 5% Vape Puffs Equal One Cig? 1 electronic cigarette pod is roughly equal to 20 cigarettes' worth of nicotine, or 200 puffs. That's a lot! Make the choice not to let nicotine control your life. #EliminateTobacco and put Poison center warns of JUUL use; 1 pod has 5% nicotine or 1 pack of 20 cigarettes