Side effects of vaping without nicotine Do electronic cigarettes create thirdhand chemical residue? Thirdhand Smoke Resource Center While vaping is not risk free, it is less harmful than tobacco Our World in Data Vaping may seem harmless, but the reality is far from it. A single disposable vape can expose you to nicotine levels equal to multiple cigarettes, making it highly addictive and harmful. It's About E Cigarettes (Vapes) Smoking and Tobacco Use CDC