What Is A Melanotic Macule? Pigmentation on the oral mucosa, hands, and feet European Journal of Internal Medicine Oral Melanotic Macule MEDizzy Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Congenital Melanocytic Macule of the Tongue in a Newborn Cureus