Experimental and Therapeutic Medicine Can Paracetamol Cause Fatty Liver? UK Medical Evidence Bolt Pharmacy Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol induced liver damage Annals of Hepatology Alan Ritchson on using testosterone to gain muscle Healthy Male Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.