Design, Biological Characterization, and Discovery of Capromorelin Derivatives as Oral Growth Hormone Secretagogue Receptor Type 1a Agonist for the Treatment of Growth Hormone Deficiency Journal of Medicinal Chemistry Ipamorelin is a growth hormone releasing peptide, not a growth hormone releasing hormone. That distinction matters. GHRHs like sermorelin signal the pituitary through the natural GHRH receptor, while GHRPs like ipamorelin work Figure 3 from Ipamorelin, the first selective growth hormone secretagogue. Semantic Scholar Direct Peptides Blog Sermorelin Therapy for Growth Hormone Production