Regarding Tylenoland Critical Thinking in Matters of Health. Apex Dental Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Sex differences in glutathione metabolism and acetaminophen toxicity View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine