Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury Vliegenthart 2017 Clinical Pharmacology & Therapeutics Wiley Online Library Tylenol depletes glutathione your livers most important protective antioxidant. Every dose chips away at it., So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8