In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation Do you feel constantly tired, weak, or lightheaded? It could be iron deficiency or iron deficiency anemia (with low hemoglobin). In women, this serious health condition is often ignored or mistaken Causes of anemia eClinpath Glutamyl Cysteine Synthetase Deficiency: A Cause of Hereditary Hemolytic Anemia