Liver injury induced by paracetamol and challenges associated with intentional and unintentional use Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. What will happen to the liver of a patient with fatty liver disease (steatosis) given 4 grams of acetaminophen (paracetamol) per day for 4 weeks? g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram The oral administration of Lacticaseibacillus casei Shirota alleviates acetaminophen induced liver injury through accelerated acetaminophen metabolism via the liver gut axis in mice mSphere