Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Health Benefits of Glutathione the biostation Best Glutathione Supplement 4 Recommendations in 2026 What is glutathione and why must we protect patient access to it? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.