Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Your Complete Guide to Glutathione Schoenwalder Health & Wellness Not only that, it depletes your #glutathione levels! 5 Factors that Deplete Glutathione