Can AllerGzyme Help Manage Food Sensitivities in Long COVID and MCAS? RTHM Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. The Key Health Benefits of S Acetyl Glutathione Water for Health S Acetyl Glutathione Active Form of Glutathione for Immune Health