Pigmented Lesions of the Oral Mucosa Pocket Dentistry Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Not Cancer! Understanding Dark Spots in the Mouth, Have you noticed a dark spot on your lips, gums, or inside your mouth? Dont panic! In this video, Dr. Shifali Arora explains melanotic macules a 40 F. 4 mm dark brown macule on lower lip. Diagnosis? Digital slide: https: kikoxp.com posts 8019. Answer https: www.youtube.com watch?v=O2yi2ir0Ubg #pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic