Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Tylenol: How much is too much of a good thing? Allied Medical Training Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health Tylenol, Autism, and Leucovorin: What Parents Need to Know.