G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Management of Athletes With G6PD Deficiency: Does Missing an Enzyme Mean Missing More Games? Shane N. Stone, Karl V. Reisig, Heather L. Saffel, Christopher M. Miles, 2020 Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency The Medical Biochemistry Page Understanding and Managing Glucose 6 Phosphate Dehydrogenase Deficiency ScienceDirect G6PD Deficiency causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione (