Medium chain fatty acid oxidation is independent of l carnitine in liver and kidney but not in heart and skeletal muscle American Journal of Physiology Gastrointestinal and Liver Physiology American Physiological Society Did you know L carnitine, a vital amino acid, is naturally produced by your body and found in various foods? While acetyl L carnitine (ALCAR) can be a beneficial supplement for some, most people get L Carnitine in Mitochondria Encyclopedia MDPI Hepatic Carnitine Palmitoyltransferase (CPT) System: Gateway to Fatty Acid Oxidation Long chain fatty acids cannot directly cross the inner mitochondrial membrane. The hepatic carnitine shuttle system, led by CPT I and L Carnitine plays an important role in the larger metabolism equation: helping your body use fat efficiently as fuel. Learn more about the science on this week's post on The Wellness Edit.