Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Frontiers Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action Tylenol's Impact on Glutathione and Liver Damage Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine