As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and PARACETAMOL DEPLETES GLUTATHIONE Natural Healing Centre ACETAMINOPHEN INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE The Journal of Pharmacology and Experimental Therapeutics Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology