Pentose phosphate pathway: phases, reactions, & metabolic roles The pentose phosphate pathway in health and disease Nature Metabolism Glucose 1 phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells: Molecular Cell HMP also known as the Pentose phosphate pathway. Consists of two irreversible oxidative rxs followed by a series of reversible Explain how Inactivity or absence of Glucose 6 phosphate dehydrogenase ; a rate limiting enzyme in the Pentose phosphate pathway could lead to oxidative stress.*