Compounded "semaglutide" is not FDA approved semaglutide.com Understanding the Legal Risks of BPC 157 and Other Unapproved Peptides Holt Law Everyone online is suddenly injecting peptides. But almost nobody understands the scienceor the regulation. The FDA recently shifted several peptides off the Category 2 safety risk list tied to compounding rules. First, that New: An FDA decision to place 19 peptides on the unsafe list was supported by numerous documented safety concerns, former officials said. Even though demand for peptide therapies has exploded since then, FDA to Convene Expert Panel on Expanding Access to Peptides Amid Safety, Regulatory Debate AJMC