Glutathione and MTHFR Methyl Life Supplements Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Glutathione: The Master Antioxidant Core Med Science Glutathione Participation in the Prevention of Cardiovascular Diseases