Melanotic macules of the tongue in a newborn Journal of the American Academy of Dermatology Oral Melanoma: A Rare but Aggressive Oral Cancer Oral melanoma is a rare and highly aggressive malignant tumor that develops from melanocytes within the oral mucosa. It most commonly affects the Initial clinical appearance with melanotic macules located on lower Download Scientific Diagram Melanotic Macules, Naevi, and Melanoma Springer Nature Link a Melanotic macule at the wetdry line of the lower lip. b Melanotic Download Scientific Diagram