Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Too Much of a Good Thing: Inadvertent Acetaminophen Overdose in a Low Weight, Elderly Patient Tylenol and Glutathione: Myths Debunked USMLE Step 2 CK Question of the Day: Altered Mental State After Over the counter pain reliever and Prescription Hydrocodone acetaminophen Osmosis Blog