Understanding the Role of Mast Cell Activation in Chronic Disease Olive leaf extract (OLE) reduces mast cell mediated allergic inflammation ScienceDirect Recruitment or activation of mast cells in the liver aggravates the accumulation of fibrosis in carbon tetrachloride induced liver injury ScienceDirect Role of glutathione in oxidative stress. During oxidative stress there Download Scientific Diagram Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.