The importance of homocysteine Alcat Education Long COVID, POTS, CFS and MTHFR: Linked by Biochemistry and Nutrition ISOM The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases Converging Evolutionary, Environmental and Clinical Ideas on Folate Metabolism The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher.