Current concepts of experimental acetaminophen (APAP) Download Scientific Diagram A guide to managing acute liver failure Cleveland Clinic Journal of Medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol And Glutathione Invigor Medical Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which