As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower Can Tylenol (acetaminophen) deplete glutathione levels in the body? Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen ScienceDirect Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize Deciphering Acetaminophen Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2Related Factor 2 as Genetic Determinants of Susceptibility to Drug Induced Liver Injury Drug Metabolism and Disposition