Why patients taking enzyme Inducers and patients with anorexia nervosa experience higher risk of paracetamol toxicity?? Acetaminophen (Paracetamol) is extensively metabolized by the liver via three main hepatic pathways: glucuronidation, sulfation, Interaction with Ethanol Alcohol Metabolism Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing) A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010
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glutathione napqi Metabolic pathway for NAPQI formation and detoxification by conjugation...