Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.