How To Tell If You're Purging Or Breaking Out Most Common Signs Does Glutathione Cause Purging? Understanding the Complex Relationship Between Glutathione and Acne Cymbiotika CYMBIOTIKA Before you spend money on glutathione, read this first. Topical, oral, injectable what actually works and what's just marketing? #funskincare #funingredientsinfographic101 9 Health Benefits of Glutathione Skin purging is a common, temporary skin breakout reaction to ingredients in certain skincare products, such as retinol and alpha hydroxy acids.