Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Mast cell activation syndrome, neck pain and the vagus nerve Mast Cell Activation Syndrome Levitas Clinic Guildford Oxidative Stress and Mitochondria Are Involved in Anaphylaxis and Mast Cell Degranulation: A Systematic Review Frontiers Ironing out COPD: ferroptosis driven immune dysregulation, metabolic rewiring, and precision therapeutic opportunities