Pigmented Lesions of the Oral Mucosa Pocket Dentistry Oral Malignant Melanoma Oral Cancer Foundation Information and Resources about Oral Head and Neck Cancer Labial melanotic macule Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after PDF) Labial Melanotic Macule Diagnosed by Dermoscopy