Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Tylenol's Impact on Glutathione and Liver Damage Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort Clinical Epigenetics Springer Nature Link Frontiers Potential adverse actions of prenatal exposure of acetaminophen to offspring