G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis: Cell Reports G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz Management of Athletes With G6PD Deficiency: Does Missing an Enzyme Mean Missing More Games? Shane N. Stone, Karl V. Reisig, Heather L. Saffel, Christopher M. Miles, 2020 Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black