Glutathione Depleting Pro Oxidant as a Selective Anticancer Therapeutic Agent ACS Omega Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Maturation Dependent Vulnerability of Oligodendrocytes to Oxidative Stress Induced Death Caused by Glutathione Depletion Journal of Neuroscience NSAIDs Depletes Glutathione Essential Formulas What is glutathione and why must we protect patient access to it?