The Truth About Why Most Glutathione Supplements Don't Work! Synergy Institute Acupuncture & Chiropractic View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link Tylenol and Glutathione: A Closer Look At Their Relationship Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.