Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ACS Omega Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Glutathione in Cancer Cell Death An integrative multi omics analysis leveraging Mendelian randomization and subsequent experimental validation prioritizes glutathione S transferase mu 5 (GSTM5) as a genomic stability related gene and a therapeutic vulnerability to PLK1 inhibition in Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ACS Omega