Pigmented Lesions of the Oral Mucosa Pocket Dentistry Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Is focal melanotic lesion potentially malignant? A case report ScienceDirect Frontiers Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy Pigmented (Purple or Brown) Lesions in the Mouth Pigmented (Purple or Brown) Lesions in the Mouth Kazemi Oral Surgery Facialart.com