Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Reduced neurogenesis in human hippocampus with Alzheimer's disease Cao 2024 Brain Pathology Wiley Online Library Neuron glia interaction through Serotonin BDNF NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain PLOS Biology Hepatocyte Growth Factor MET Activator Rescues Working Memory Deficits after Repeated Mild Traumatic Brain Injury Katelyn A. Martino, Arush Nakhre, Renee M. Demarest, David M. Devilbiss, 2025 Small molecule activation of the neurotrophin hepatocyte growth factor to treat Alzheimer disease
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dihexa promotes neurogenesis Neurogenesis and Gliogenesis as Potential Contributors to Neurorepair after Brain Damage