Can Tylenol (acetaminophen) deplete glutathione levels in the body? Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, The multiple mechanisms and modes of cell death after acetaminophen overdose Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Ferroptosis and intrinsic drug induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective EurekAlert!