Best Glutathione Supplement 4 Recommendations in 2026 What is glutathione and why must we protect patient access to it? Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Glutathione depleting polymer delivering chlorin e6 for enhancing photodynamic therapy RSC Advances (RSC Publishing) Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.