Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst Pentose Phosphate Pathway Reactions in Photosynthesizing Cells 6.3: The Pentose Phosphate Pathway Biology LibreTexts A metabolic switch to the pentose phosphate pathway induces radiation resistance in pancreatic cancer Radiotherapy and Oncology Pentose Phosphate Pathway and Nicotinamide Adenine Dinucleotide Phosphate