S Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent These highlights do not include all the information needed to use TRETINOIN Gel safely and effectively. See full prescribing information for TRETINOIN Gel. TRETINOIN Gel, 0.05%For topical use Initial U.S. Approval: 1973 S adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility Journal of Hepatology S adenosylmethionine upregulates the angiotensin receptor binding protein ATRAP via the methylation of HuR in NAFLD Cell Death & Disease Hepatic levels of S adenosylmethionine regulate the adaptive response to fasting: Cell Metabolism