Midline Dressing Change PICC Line and Midline Catheter Care Vascular Wellness Every 7 days we change my PICC line dressings to keep my line clean and safe. Last night we changed it again at home with speciality supplies. Ps: medical glue into an open wound flipping HURTS!! But Dear Colleague, This is my weekly PICC line dressing change. I am not a licensed RN and these are purely my experiences in the hospital. If you'd like to follow my story, PleaSE! LiKE!