Large, Spreading Rash After Illness Clinical Advisor DRESS is an unexpected, severe reaction to medication. Several organs are commonly affected including the skin, liver, kidneys, lungs and heart. Not all of these organs may be affected at any one DRESS Syndrome symptoms vary by person. Reactions often occur in 2 stages: Early Reaction (like fever, rash, & enlarged lymph nodes) & Progressive Reaction (like peeling skin, facial swelling, & affected organs). Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Pediatric EM Morsels Erosive cheilitis as an early manifestation in DRESS syndrome